This drug comes with several warnings.

Allergy warning

Beprin can cause a severe allergic reaction. Symptoms can include: skin tissue death at the injection site, chills, fever, rash, hives, itching, burning, shortness of breath, swelling of your face, lips, throat, or tongue If you develop these symptoms, go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Beprin is derived from animal tissue. It should be used with caution in people with a history of allergy to this drug or to pig proteins. Taking beprin could be fatal (cause death).

Warnings for people with certain health conditions

For people with pig protein sensitivity: Do not take this drug. This drug is made from pork tissue and can cause a life-threatening allergic reaction in people who are sensitive or allergic to other pig proteins.

For people with uncontrolled high blood pressure: You are at an increased risk of bleeding from this drug. Talk to your doctor before using beprin.

For people with bleeding or clotting problems: If you have abnormal bleeding or a condition that puts you at an increased risk of bleeding, using beprin could increase your risk even more. Use Beprin with caution.

For people with a history of stomach ulcers or bleeding: If you have active stomach ulcers, you should not use beprin. It could make your ulcers worse and cause dangerous bleeding. If you have a history of stomach ulcers but don’t have active ulcers, using beprin puts you at an increased risk of bleeding. You should talk to your doctor before using beprin.

For people with kidney disease: If you have severe kidney disease or a history of kidney disease, taking beprin can increase your risk of bleeding. Talk to your doctor before using beprin.

For people with liver disease: If you have severe liver disease or a history of liver disease, taking beprin can increase your risk of bleeding. Talk to your doctor before using beprin.

For people with asthma or sulfite sensitivity: People with asthma are likely to be sensitive to sulfites. Sulfites can cause a life-threatening allergic reaction in some people. Some forms of this drug contain sulfites. Talk to your doctor about using a sulfite-free version of beprin.

Warnings for other groups

For pregnant women: Research in animals has shown negative effects to the fetus when the mother uses beprin. However, there haven’t been enough studies done in humans to be certain how the drug might affect the fetus. Talk to your doctor if you’re pregnant or plan to become pregnant. This drug should only be used if the potential benefit justifies the potential risk. Ask your doctor if using the preservative-free version of beprin would be better for you than the version that contains benzyl alcohol. If you become pregnant while taking this drug, call your doctor right away.

For women who are breastfeeding: Beprin is unlikely to pass into breast milk and be absorbed by an infant who is breastfed. Talk to your doctor about the best way to feed your child while you’re taking beprin. Some forms of beprin contain a preservative called benzyl alcohol. This ingredient can slow down the central nervous system in some infants. It has also caused trouble breathing and changes in the blood chemistry in some infants. These effects can be deadly. If you breastfeed your child, talk to your doctor about preservative-free beprin.

For seniors: If you are older than 60 years, you may be at a higher risk of bleeding. Beprin also increases your risk of bleeding, so your doctor may start you on a reduced dosage.

For children: This medication has not been studied in children. Dosage recommendations are based on clinical experience. Newborns and infants should receive preservative-free beprin. The preservative benzyl alcohol has been linked to serious side effects and even death in newborns and infants.